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Physical illnesses which causes fatigue, pain, or general feelings of malaise could also be one of the reason for low or lack of sex desire. Hormone deficiencies may occasionally be implicated. Psychological conditions such as depression and excessive stress may inhibit sexual interest.

It may also be associated with other sex problems, and sometimes may be caused by them. For example, the woman who is unable to have orgasm or has pain during intercourse, or the man who has erection problems (impotence) or retarded ejaculation, may lose interest in sex because it is commonly associated with failure or is not very pleasurable.